There may be differences, depending on the compression used for the source image.
If there seem to be any problems with the output GIF file (missing frames/strange artifacts/flickering), try to select a different option under the 'Crop with' dropdown. It also features the Autocrop option, for trimming off transparent pixels around the image.
You can select one of the predefined aspect ratios: square, 4:3, 16:9, 3:2, 2:1, golden ratio, or freely select the area you want to crop. You can also fill in the desired dimensions (in pixels) manually. Just upload the GIF and use your mouse or trackpad to select the part of the image you want to crop/trim. A simple online tool for cropping and slicing animated GIF, WebP, and PNG images.